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Image Search Results
Journal: Frontiers in Cell and Developmental Biology
Article Title: ALD-R491 regulates vimentin filament stability and solubility, cell contractile force, cell migration speed and directionality
doi: 10.3389/fcell.2022.926283
Figure Lengend Snippet: R491 increases the fraction and number of small focal adhesions. (A) Representative confocal microscopy images of BJ-Ras cells treated with 5 μM control or R491, showing vimentin, phospho-tyrosine, F-actin, as indicated, and merged images with vimentin (red), phospho-tyrosine (yellow), actin (green) and nuclei (blue). Inset images: magnified views of boxed areas in the larger images. Scale bars: 10 μm. The graphs show (B) the average size of cell-matrix adhesions/per cell, with n = 516 and 478 focal adhesions for control- and R491-treated cells, respectively, and (C) the frequency distribution of the binned sizes of focal adhesions of control- (black) or R491- (grey) treated cells. ** p ≤ 0.01. The difference in the frequency distribution was significant with p ≤ 0.0001.
Article Snippet: The mean values of the aspect ratio, cell migration speed and persistence, cells from which debris is detached and left behind during migration, filament distribution, as well as
Techniques: Confocal Microscopy, Control